Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms

Despite significant advances, the molecular identity of the cytotoxic species populated during in vivo amyloid formation crucial for the understanding of neurodegenerative disorders is yet to be revealed. In this study lysozyme prefibrillar oligomers and fibrils in both mature and sonicated states h...

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Vydáno v:J Biol Chem
Hlavní autoři: Harte, Níal P., Klyubin, Igor, McCarthy, Eoin K., Min, Soyoung, Garrahy, Sarah Ann, Xie, Yongjing, Davey, Gavin P., Boland, John J., Rowan, Michael J., Mok, K. Hun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653689/
https://ncbi.nlm.nih.gov/pubmed/26221033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676072
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