Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms

Despite significant advances, the molecular identity of the cytotoxic species populated during in vivo amyloid formation crucial for the understanding of neurodegenerative disorders is yet to be revealed. In this study lysozyme prefibrillar oligomers and fibrils in both mature and sonicated states h...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Harte, Níal P., Klyubin, Igor, McCarthy, Eoin K., Min, Soyoung, Garrahy, Sarah Ann, Xie, Yongjing, Davey, Gavin P., Boland, John J., Rowan, Michael J., Mok, K. Hun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653689/
https://ncbi.nlm.nih.gov/pubmed/26221033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.676072
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