An anthrax toxin variant with an improved activity in tumor targeting

Anthrax lethal toxin (LT) is an A-B type toxin secreted by Bacillus anthracis, consisting of the cellular binding moiety, protective antigen (PA), and the catalytic moiety, lethal factor (LF). To target cells, PA binds to cell-surface receptors and is then proteolytically processed forming a LF-bind...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Wein, Alexander N., Peters, Diane E., Valivullah, Zaheer, Hoover, Benjamin J., Tatineni, Aparna, Ma, Qian, Fattah, Rasem, Bugge, Thomas H., Leppla, Stephen H., Liu, Shihui
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653645/
https://ncbi.nlm.nih.gov/pubmed/26584669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16267
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