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Bismaleimide cross‐linked anthrax toxin forms functional octamers with high specificity in tumor targeting

In recent years, anthrax toxin has been reengineered to act as a highly specific antiangiogenic cancer therapeutic, shown to kill tumors in animal models. This has been achieved by modifying protective antigen (PA) so that its activation and toxicity require the presence of two proteases, matrix met...

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Bibliografische gegevens
Gepubliceerd in:Protein Sci
Hoofdauteurs: Fischer, Elyse S., Campbell, Warren A., Liu, Shihui, Ghirlando, Rodolfo, Fattah, Rasem J., Bugge, Thomas H., Leppla, Stephen H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511737/
https://ncbi.nlm.nih.gov/pubmed/30942916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3613
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