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Bismaleimide cross‐linked anthrax toxin forms functional octamers with high specificity in tumor targeting

In recent years, anthrax toxin has been reengineered to act as a highly specific antiangiogenic cancer therapeutic, shown to kill tumors in animal models. This has been achieved by modifying protective antigen (PA) so that its activation and toxicity require the presence of two proteases, matrix met...

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Bibliografski detalji
Izdano u:Protein Sci
Glavni autori: Fischer, Elyse S., Campbell, Warren A., Liu, Shihui, Ghirlando, Rodolfo, Fattah, Rasem J., Bugge, Thomas H., Leppla, Stephen H.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6511737/
https://ncbi.nlm.nih.gov/pubmed/30942916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3613
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