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A versatile transgenic allele for mouse overexpression studies

For the analysis of gene function in vivo, gene overexpression in the mouse provides an alternative to loss-of-function knock-out approaches and can help reveal phenotypes where compensatory mechanisms are at play. Furthermore, when multiple lines overexpressing a gene-of-interest at varying levels...

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Publicado en:Mamm Genome
Autores principales: Dolatshad, Hamid, Biggs, Daniel, Diaz, Rebeca, Hortin, Nicole, Preece, Christopher, Davies, Benjamin
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653235/
https://ncbi.nlm.nih.gov/pubmed/26369329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00335-015-9602-y
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