CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice

Here, we show CRISPR/Cas9-based targeted somatic multiplex-mutagenesis and its application for high-throughput analysis of gene function in mice. Using hepatic single guide RNA (sgRNA) delivery, we targeted large gene sets to induce hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Weber, Julia, Öllinger, Rupert, Friedrich, Mathias, Ehmer, Ursula, Barenboim, Maxim, Steiger, Katja, Heid, Irina, Mueller, Sebastian, Maresch, Roman, Engleitner, Thomas, Gross, Nina, Geumann, Ulf, Fu, Beiyuan, Segler, Angela, Yuan, Detian, Lange, Sebastian, Strong, Alexander, de la Rosa, Jorge, Esposito, Irene, Liu, Pentao, Cadiñanos, Juan, Vassiliou, George S., Schmid, Roland M., Schneider, Günter, Unger, Kristian, Yang, Fengtang, Braren, Rickmer, Heikenwälder, Mathias, Varela, Ignacio, Saur, Dieter, Bradley, Allan, Rad, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653208/
https://ncbi.nlm.nih.gov/pubmed/26508638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1512392112
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