A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function

The immunomodulatory drug (IMiD) thalidomide and its structural analogs lenalidomide and pomalidomide are highly effective in treating clinical indications. Thalidomide binds to cereblon (CRBN), a substrate receptor of the cullin-4 really interesting new gene (RING) E3 ligase complex. Here, we exami...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FASEB J
Egile Nagusiak: Liu, Yaobin, Huang, Xiangao, He, Xian, Zhou, Yanqing, Jiang, Xiaogang, Chen-Kiang, Selina, Jaffrey, Samie R., Xu, Guoqiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Federation of American Societies for Experimental Biology 2015
Gaiak:
Research Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653049/
https://ncbi.nlm.nih.gov/pubmed/26231201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-274050
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