A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function

The immunomodulatory drug (IMiD) thalidomide and its structural analogs lenalidomide and pomalidomide are highly effective in treating clinical indications. Thalidomide binds to cereblon (CRBN), a substrate receptor of the cullin-4 really interesting new gene (RING) E3 ligase complex. Here, we exami...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:FASEB J
मुख्य लेखकों: Liu, Yaobin, Huang, Xiangao, He, Xian, Zhou, Yanqing, Jiang, Xiaogang, Chen-Kiang, Selina, Jaffrey, Samie R., Xu, Guoqiang
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Federation of American Societies for Experimental Biology 2015
विषय:
Research Communication
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653049/
https://ncbi.nlm.nih.gov/pubmed/26231201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-274050
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