A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function

The immunomodulatory drug (IMiD) thalidomide and its structural analogs lenalidomide and pomalidomide are highly effective in treating clinical indications. Thalidomide binds to cereblon (CRBN), a substrate receptor of the cullin-4 really interesting new gene (RING) E3 ligase complex. Here, we exami...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Liu, Yaobin, Huang, Xiangao, He, Xian, Zhou, Yanqing, Jiang, Xiaogang, Chen-Kiang, Selina, Jaffrey, Samie R., Xu, Guoqiang
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2015
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653049/
https://ncbi.nlm.nih.gov/pubmed/26231201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.15-274050
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