ROS1 amplification mediates resistance to gefitinib in glioblastoma cells

Glioblastoma (GBM) is the most aggressive brain tumor in adults and remains incurable despite multimodal intensive treatment regimens. The majority of GBM tumors show a mutated or overexpressed EGFR, however, tumors treated with tyrosine kinase inhibitors (TKIs) will inevitably recur highlighting th...

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Gardado en:
Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Aljohani, Hashim, Koncar, Robert F., Zarzour, Ahmad, Park, Byung Sun, Lee, So Ha, Bahassi, El Mustapha
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2015
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653012/
https://ncbi.nlm.nih.gov/pubmed/25978031
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