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Gefitinib-mediated Reactive Oxygen Specie (ROS) Instigates Mitochondrial Dysfunction and Drug Resistance in Lung Cancer Cells

Therapeutic benefits offered by tyrosine kinase inhibitors (TKIs), such as gefitinib (Iressa) and erlotinib (Tarceva), are limited due to the development of resistance, which contributes to treatment failure and cancer-related mortality. The aim of this study was to elucidate mechanistic insight int...

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Foilsithe in:J Biol Chem
Main Authors: Okon, Imoh S., Coughlan, Kathleen A., Zhang, Miao, Wang, Qiongxin, Zou, Ming-Hui
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423695/
https://ncbi.nlm.nih.gov/pubmed/25681445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.631580
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