Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity

The MRX complex together with Sae2 initiates resection of DNA double-strand breaks (DSBs) to generate single-stranded DNA (ssDNA) that triggers homologous recombination. The absence of Sae2 not only impairs DSB resection, but also causes prolonged MRX binding at the DSBs that leads to persistent Tel...

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Udgivet i:PLoS Genet
Main Authors: Gobbini, Elisa, Villa, Matteo, Gnugnoli, Marco, Menin, Luca, Clerici, Michela, Longhese, Maria Pia
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4652893/
https://ncbi.nlm.nih.gov/pubmed/26584331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005685
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