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The progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.

The protein kinase A stimulator cAMP can potentiate the ability of progestins to induce the transactivation function of the human progesterone receptor (hPR). We questioned in the present study whether cAMP could functionally cooperate with the progestin antagonist RU486. In T47D human breast cancer...

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Détails bibliographiques
Auteurs principaux: Beck, C A, Weigel, N L, Moyer, M L, Nordeen, S K, Edwards, D P
Format: Artigo
Langue:Inglês
Publié: 1993
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC46527/
https://ncbi.nlm.nih.gov/pubmed/8389450
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