In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNA.
The binding of a steroid hormone to its receptor elicits a sequence of events: activation of the receptor (probably through dissociation from a complex of heat shock proteins), dimerization, binding to hormone responsive elements, and finally modulation of gene transcription. RU 486, the first antip...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1993
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46523/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8506282/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.10.4421 |
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