Application of Mannich Bases to the Synthesis of Hydroxymethylated Isoflavonoids As Potential Antineoplastic Agents

The regiospecific Mannich aminomethylation of 7-hydroxyisoflavonoids using bis(N,N-dimethylamino)methane afforded C-8 substituted N,N-dimethylaminomethyl adducts, and the regioselective aminomethylation of 5-hydroxy-7-methoxyisoflavonoids afforded predominantly the C-6 substituted N,N-dimethylaminom...

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Veröffentlicht in:Org Biomol Chem
Hauptverfasser: Frasinyuk, Mykhaylo S., Mrug, Galyna P., Bondarenko, Svitlana P., Sviripa, Vitaliy M., Zhang, Wen, Cai, Xianfeng, Fiandalo, Michael V., Mohler, James L., Liu, Chunming, Watt, David S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651832/
https://ncbi.nlm.nih.gov/pubmed/26416505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob01828e
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