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Myeloid lineage skewing due to exacerbated NF-κB signaling facilitates osteopenia in Scurfy mice
Immune surveillance through Foxp3+ regulatory T cells plays a crucial role in bone homeostasis. Scurfy, the mouse model of autoimmune IPEX syndrome, bears a loss-of-function mutation in Foxp3 that leads to multi-organ inflammation. Herein, we report that scurfy mice exhibit severe bone loss mediated...
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| Publicado no: | Cell Death Dis |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4650554/ https://ncbi.nlm.nih.gov/pubmed/25880090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.87 |
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