PHRF1 promotes genome integrity by modulating non-homologous end-joining

Methylated histone readers are critical for chromatin dynamics, transcription, and DNA repair. Human PHRF1 contains a plant homeodomain (PHD) that recognizes methylated histones and a RING domain, which ubiquitinates substrates. A recent study reveals that PHRF1 is a tumor suppressor that promotes T...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Chang, C-F, Chu, P-C, Wu, P-Y, Yu, M-Y, Lee, J-Y, Tsai, M-D, Chang, M-S
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4650548/
https://ncbi.nlm.nih.gov/pubmed/25855964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.81
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