Meropenem-RPX7009 Concentrations in Plasma, Epithelial Lining Fluid, and Alveolar Macrophages of Healthy Adult Subjects

The steady-state concentrations of meropenem and the β-lactamase inhibitor RPX7009 in plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations were obtained in 25 healthy, nonsmoking adult subjects. Subjects received a fixed combination of meropenem (2 g) and RPX7009 (2 g)...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Wenzler, Eric, Gotfried, Mark H., Loutit, Jeffrey S., Durso, Stephanie, Griffith, David C., Dudley, Michael N., Rodvold, Keith A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649232/
https://ncbi.nlm.nih.gov/pubmed/26349830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01713-15
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