Penetration of GSK1322322 into Epithelial Lining Fluid and Alveolar Macrophages as Determined by Bronchoalveolar Lavage

GSK1322322 is a potent peptide deformylase inhibitor with in vitro and in vivo activity against multidrug-resistant skin and respiratory pathogens. This report provides plasma and intrapulmonary pharmacokinetics, safety, and tolerability of GSK1322322 after repeat (twice daily intravenous dosing for...

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Bibliografiska uppgifter
Huvudupphovsmän: Naderer, Odin J., Rodvold, Keith A., Jones, Lori S., Zhu, John Z., Bowen, Chester L., Chen, Liangfu, Dumont, Etienne
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2014
Ämnen:
Pharmacology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910803/
https://ncbi.nlm.nih.gov/pubmed/24189245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01836-13
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