Validation and Application of a Liquid Chromatography-Tandem Mass Spectrometry Method To Determine the Concentrations of Sofosbuvir Anabolites in Cells

Sofosbuvir (SOF) is a highly efficacious and well-tolerated uridine nucleotide analog that inhibits the hepatitis C virus (HCV) NS5B polymerase enzyme. SOF is administered as a prodrug, which undergoes intracellular phosphorylation by host enzymes to a monophosphate, diphosphate, and finally a pharm...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Rower, Joseph E., Jimmerson, Leah C., Chen, Xinhui, Zheng, Jia-Hua, Hodara, Ariel, Bushman, Lane R., Anderson, Peter L., Kiser, Jennifer J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649184/
https://ncbi.nlm.nih.gov/pubmed/26416874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01693-15
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