Serum and cellular ribavirin pharmacokinetic and concentration–effect analysis in HCV patients receiving sofosbuvir plus ribavirin

OBJECTIVES: Ribavirin concentrations may impact hepatitis C virus (HCV) treatment outcome. We modelled ribavirin serum and intracellular ribavirin monophosphate (RBV-MP) and ribavirin triphosphate (RBV-TP) pharmacokinetics in red blood cells (RBC) using samples collected during the NIAID SPARE trial...

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Dettagli Bibliografici
Pubblicato in:J Antimicrob Chemother
Autori principali: Rower, Joseph E., Meissner, Eric G., Jimmerson, Leah C., Osinusi, Anu, Sims, Zayani, Petersen, Tess, Bushman, Lane R., Wolfe, Pamela, McHutchison, John G., Kottilil, Shyamasundaran, Kiser, Jennifer J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4542804/
https://ncbi.nlm.nih.gov/pubmed/25971261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv122
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