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Polymyxin Susceptibility in Pseudomonas aeruginosa Linked to the MexXY-OprM Multidrug Efflux System

The ribosome-targeting antimicrobial, spectinomycin (SPC), strongly induced the mexXY genes of the MexXY-OprM multidrug efflux system in Pseudomonas aeruginosa and increased susceptibility to the polycationic antimicrobials polymyxin B and polymyxin E, concomitant with a decrease in expression of th...

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Bibliografski detalji
Izdano u:Antimicrob Agents Chemother
Glavni autori: Poole, Keith, Lau, Calvin Ho-Fung, Gilmour, Christie, Hao, Youai, Lam, Joseph S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649153/
https://ncbi.nlm.nih.gov/pubmed/26369970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01785-15
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