Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib

Imatinib resistance is an emerging problem in the therapy of chronic myeloid leukemia (CML). Because imatinib induces apoptosis, which may be coupled with mitochondria and DNA damage is a prototype apoptosis-inducing factor, we hypothesized that imatinib-sensitive and -resistant CML cells might diff...

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Bibliografski detalji
Izdano u:Biomed Res Int
Glavni autori: Synowiec, Ewelina, Hoser, Grazyna, Bialkowska-Warzecha, Jolanta, Pawlowska, Elzbieta, Skorski, Tomasz, Blasiak, Janusz
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2015
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649080/
https://ncbi.nlm.nih.gov/pubmed/26618175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/673512
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