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Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib

Imatinib resistance is an emerging problem in the therapy of chronic myeloid leukemia (CML). Because imatinib induces apoptosis, which may be coupled with mitochondria and DNA damage is a prototype apoptosis-inducing factor, we hypothesized that imatinib-sensitive and -resistant CML cells might diff...

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Bibliografiske detaljer
Udgivet i:Biomed Res Int
Main Authors: Synowiec, Ewelina, Hoser, Grazyna, Bialkowska-Warzecha, Jolanta, Pawlowska, Elzbieta, Skorski, Tomasz, Blasiak, Janusz
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649080/
https://ncbi.nlm.nih.gov/pubmed/26618175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/673512
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