Doxorubicin Differentially Induces Apoptosis, Expression of Mitochondrial Apoptosis-Related Genes, and Mitochondrial Potential in BCR-ABL1-Expressing Cells Sensitive and Resistant to Imatinib

Imatinib resistance is an emerging problem in the therapy of chronic myeloid leukemia (CML). Because imatinib induces apoptosis, which may be coupled with mitochondria and DNA damage is a prototype apoptosis-inducing factor, we hypothesized that imatinib-sensitive and -resistant CML cells might diff...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Synowiec, Ewelina, Hoser, Grazyna, Bialkowska-Warzecha, Jolanta, Pawlowska, Elzbieta, Skorski, Tomasz, Blasiak, Janusz
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4649080/
https://ncbi.nlm.nih.gov/pubmed/26618175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/673512
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