Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin

The association and dissociation of DNA damage response (DDR) factors with damaged chromatin occurs dynamically, which is crucial for the activation of DDR signaling in a spatiotemporal manner. We previously showed that the TIP60 histone acetyltransferase complex acetylates histone H2AX, to facilita...

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Publicat a:Mol Cell Biol
Autors principals: Ikura, Masae, Furuya, Kanji, Matsuda, Shun, Matsuda, Ryo, Shima, Hiroki, Adachi, Jun, Matsuda, Tomonari, Shiraki, Takuma, Ikura, Tsuyoshi
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648820/
https://ncbi.nlm.nih.gov/pubmed/26438602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00757-15
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