Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa

BACKGROUND: Viruses can evade immune surveillance, but the underlying mechanisms are insufficiently understood. Here, we sought to understand the mechanisms by which natural killer (NK) cells recognize HIV-1-infected cells and how this virus can evade NK-cell-mediated immune pressure. METHODS AND FI...

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Publicado no:PLoS Med
Main Authors: Hölzemer, Angelique, Thobakgale, Christina F., Jimenez Cruz, Camilo A., Garcia-Beltran, Wilfredo F., Carlson, Jonathan M., van Teijlingen, Nienke H., Mann, Jaclyn K., Jaggernath, Manjeetha, Kang, Seung-gu, Körner, Christian, Chung, Amy W., Schafer, Jamie L., Evans, David T., Alter, Galit, Walker, Bruce D., Goulder, Philip J., Carrington, Mary, Hartmann, Pia, Pertel, Thomas, Zhou, Ruhong, Ndung’u, Thumbi, Altfeld, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648589/
https://ncbi.nlm.nih.gov/pubmed/26575988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001900
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