Cumulus Cells Block Oocyte Meiotic Resumption via Gap Junctions in Cumulus Oocyte Complexes Subjected to DNA Double-Strand Breaks

During mammalian oocyte growth, genomic DNA may accumulate DNA double-strand breaks (DSBs) induced by factors such as reactive oxygen species. Recent evidence demonstrated that slight DSBs do not activate DNA damage checkpoint proteins in denuded oocytes. These oocytes, even with DNA DSBs, can resum...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Sun, Ming-Hong, Zheng, Jie, Xie, Feng-Yun, Shen, Wei, Yin, Shen, Ma, Jun-Yu
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648486/
https://ncbi.nlm.nih.gov/pubmed/26575642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0143223
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