Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy

Aging is the single biggest risk factor for malignant transformation. Among the most common age-associated malignancies are non-melanoma skin cancers, comprising the most common types of human cancer. Here we show that mutant H-Ras activation in mouse epidermis, a frequent event in cutaneous squamou...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Golomb, L, Sagiv, A, Pateras, I S, Maly, A, Krizhanovsky, V, Gorgoulis, V G, Oren, M, Ben-Yehuda, A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648323/
https://ncbi.nlm.nih.gov/pubmed/26434982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2015.21
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