CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations against glioma models

BACKGROUND: The prognosis of glioblastoma (GBM) remains poor; therefore, effective therapeutic strategies need to be developed. CD40 is a costimulatory molecule whose agonistic antibody has been shown to activate antitumor effects. Recently, CD40 has been extensively targeted for immunotherapeutic p...

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Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Chonan, Masashi, Saito, Ryuta, Shoji, Takuhiro, Shibahara, Ichiyo, Kanamori, Masayuki, Sonoda, Yukihiko, Watanabe, Mika, Kikuchi, Toshiaki, Ishii, Naoto, Tominaga, Teiji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
Basic and Translational Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648302/
https://ncbi.nlm.nih.gov/pubmed/26008605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov090
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