Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models

BACKGROUND: Glioblastoma is one of the most malignant brain tumors in adults and has a dismal prognosis. In a previous report, we reported that CD40, a TNF-R-related cell surface receptor, and its ligand CD40L were associated with glioma outcomes. Here we attempted to activate CD40 signaling in the...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Shoji, Takuhiro, Saito, Ryuta, Chonan, Masashi, Shibahara, Ichiyo, Sato, Aya, Kanamori, Masayuki, Sonoda, Yukihiko, Kondo, Toru, Ishii, Naoto, Tominaga, Teiji
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2016
Pynciau:
Basic and Translational Investigations
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933484/
https://ncbi.nlm.nih.gov/pubmed/26917236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now023
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