OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy

BACKGROUND: Glioblastoma is the most malignant human brain tumor and has a dismal prognosis; however, some patients show long-term survival. The interaction between the costimulatory molecule OX40 and its ligand OX40L generates key signals for T-cell activation. The augmentation of this interaction...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Cancer
Hauptverfasser: Shibahara, Ichiyo, Saito, Ryuta, Zhang, Rong, Chonan, Masashi, Shoji, Takuhiro, Kanamori, Masayuki, Sonoda, Yukihiko, Kumabe, Toshihiro, Kanehira, Masahiko, Kikuchi, Toshiaki, So, Takanori, Watanabe, Takashi, Takahashi, Hiroaki, Iwabuchi, Erina, Tanaka, Yuetsu, Shibahara, Yukiko, Sasano, Hironobu, Ishii, Naoto, Tominaga, Teiji
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4339477/
https://ncbi.nlm.nih.gov/pubmed/25744203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0307-3
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