Potent and Selective Modulation of the RhlR Quorum Sensing Receptor using Non-Native Ligands – An Emerging Target for Virulence Control in Pseudomonas aeruginosa

Pseudomonas aeruginosa uses N-acylated L-homoserine lactone signals and a triumvirate of LuxR-type receptor proteins – LasR, RhlR, and QscR – for quorum sensing (QS). Each of these receptors can contribute to QS activation or repression, and thereby, the control of myriad virulence phenotypes in thi...

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Gepubliceerd in:Chembiochem
Hoofdauteurs: Eibergen, Nora R., Moore, Joseph D., Mattmann, Margrith E., Blackwell, Helen E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648260/
https://ncbi.nlm.nih.gov/pubmed/26460240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500357
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