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Pharmacokinetics of PEGylated recombinant human endostatin (M(2)ES) in rats
AIM: M(2)ES is PEGylated recombinant human endostatin. In this study we investigated the pharmacokinetics, tissue distribution, and excretion of M(2)ES in rats. METHODS: (125)I-radiolabeled M(2)ES was administered to rats by intravenous bolus injection at 3 mg/kg. The pharmacokinetics, tissue distri...
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| Veröffentlicht in: | Acta Pharmacol Sin |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4648114/ https://ncbi.nlm.nih.gov/pubmed/26027657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.16 |
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