Pharmacokinetics of PEGylated recombinant human endostatin (M(2)ES) in rats

AIM: M(2)ES is PEGylated recombinant human endostatin. In this study we investigated the pharmacokinetics, tissue distribution, and excretion of M(2)ES in rats. METHODS: (125)I-radiolabeled M(2)ES was administered to rats by intravenous bolus injection at 3 mg/kg. The pharmacokinetics, tissue distri...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Li, Zuo-gang, Jia, Lin, Guo, Li-fang, Yu, Min, Sun, Xu, Nie, Wen, Fu, Yan, Rao, Chun-ming, Wang, Jun-zhi, Luo, Yong-zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4648114/
https://ncbi.nlm.nih.gov/pubmed/26027657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.16
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