Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol

BACKGROUND: Both the number and size of tumours in NF1 patients increase in response to the rise in steroid hormones seen at puberty and during pregnancy. The size of tumours decreases after delivery, suggesting that hormone-targeting therapy might provide a viable new NF1 treatment approach. Our ea...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Br J Cancer
Egile Nagusiak: Shen, Yu-chi, Upadhyayula, Ravi, Cevallos, Stephanie, Messick, Ryan J, Hsia, Tammy, Leese, Mathew P, Jewett, Douglas M, Ferrer-Torres, Daysha, Roth, Therese M, Dohle, Wolfgang, Potter, Barry V L, Barald, Kate F
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Translational Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647869/
https://ncbi.nlm.nih.gov/pubmed/26461061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.345
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