Targeted NF1 cancer therapeutics with multiple modes of action: small molecule hormone-like agents resembling the natural anticancer metabolite, 2-methoxyoestradiol

BACKGROUND: Both the number and size of tumours in NF1 patients increase in response to the rise in steroid hormones seen at puberty and during pregnancy. The size of tumours decreases after delivery, suggesting that hormone-targeting therapy might provide a viable new NF1 treatment approach. Our ea...

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Udgivet i:Br J Cancer
Main Authors: Shen, Yu-chi, Upadhyayula, Ravi, Cevallos, Stephanie, Messick, Ryan J, Hsia, Tammy, Leese, Mathew P, Jewett, Douglas M, Ferrer-Torres, Daysha, Roth, Therese M, Dohle, Wolfgang, Potter, Barry V L, Barald, Kate F
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647869/
https://ncbi.nlm.nih.gov/pubmed/26461061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.345
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