IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation

BACKGROUND: Local tumor control by standard fractionated radiotherapy (RT) remains poor because of tumor resistance to radiation (radioresistance). It has been suggested that cancer stem cells (CSCs) are more radioresistant than non-CSCs. In previous studies, we have shown IL-6 promotes self-renewal...

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Bibliografiske detaljer
Udgivet i:Radiat Oncol
Main Authors: Chen, Yuhchyau, Zhang, Fuquan, Tsai, Ying, Yang, Xiadong, Yang, Li, Duan, Shanzhou, Wang, Xin, Keng, Peter, Lee, Soo Ok
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647293/
https://ncbi.nlm.nih.gov/pubmed/26572130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13014-015-0534-1
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