IL-6 signaling promotes DNA repair and prevents apoptosis in CD133+ stem-like cells of lung cancer after radiation

BACKGROUND: Local tumor control by standard fractionated radiotherapy (RT) remains poor because of tumor resistance to radiation (radioresistance). It has been suggested that cancer stem cells (CSCs) are more radioresistant than non-CSCs. In previous studies, we have shown IL-6 promotes self-renewal...

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Veröffentlicht in:Radiat Oncol
Hauptverfasser: Chen, Yuhchyau, Zhang, Fuquan, Tsai, Ying, Yang, Xiadong, Yang, Li, Duan, Shanzhou, Wang, Xin, Keng, Peter, Lee, Soo Ok
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647293/
https://ncbi.nlm.nih.gov/pubmed/26572130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13014-015-0534-1
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