Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress

Simvastatin, an HMG-CoA reductase inhibitor, has lung vascular-protective effects that are associated with decreased agonist-induced integrin β4 (ITGB4) tyrosine phosphorylation. Accordingly, we hypothesized that endothelial cell (EC) protection by simvastatin is dependent on these effects and sough...

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Pubblicato in:Sci Rep
Autori principali: Chen, Weiguo, Epshtein, Yulia, Ni, Xiuquin, Dull, Randal O., Cress, Anne E., Garcia, Joe G.N., Jacobson, Jeffrey R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4647208/
https://ncbi.nlm.nih.gov/pubmed/26572585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16529
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