Informatic Deconvolution of Biased GPCR Signaling Mechanisms from in vivo Pharmacological Experimentation

Ligands possessing different physico-chemical structures productively interact with G protein-coupled receptors generating distinct downstream signaling events due to their abilities to activate/select idiosyncratic receptor entities (‘receptorsomes’) from the full spectrum of potential receptor par...

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Bibliografske podrobnosti
izdano v:Methods
Main Authors: Maudsley, Stuart, Martin, Bronwen, Janssens, Jonathan, Etienne, Harmonie, Jushaj, Areta, van Gastel, Jaana, Willemsen, Ann, Chen, Hongyu, Gesty-Palmer, Diane, Luttrell, Louis M.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646739/
https://ncbi.nlm.nih.gov/pubmed/25986936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2015.05.013
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