The regulatory machinery of neurodegeneration in in vitro models of amyotrophic lateral sclerosis

Neurodegenerative phenotypes reflect complex, time-dependent molecular processes, whose elucidation may reveal neuronal class-specific therapeutic targets. The current focus in neurodegeneration has been on individual genes and pathways. In contrast, we assembled a genome-wide regulatory model (henc...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Ikiz, Burcin, Alvarez, Mariano J., Ré, Diane B., Le Verche, Virginia, Politi, Kristin, Lotti, Francesco, Phani, Sudarshan, Pradhan, Radhika, Yu, Changhao, Croft, Gist F., Jacquier, Arnaud, Henderson, Christopher E., Califano, Andrea, Przedborski, Serge
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646662/
https://ncbi.nlm.nih.gov/pubmed/26146077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.019
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