The regulatory machinery of neurodegeneration in in vitro models of amyotrophic lateral sclerosis

Neurodegenerative phenotypes reflect complex, time-dependent molecular processes, whose elucidation may reveal neuronal class-specific therapeutic targets. The current focus in neurodegeneration has been on individual genes and pathways. In contrast, we assembled a genome-wide regulatory model (henc...

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Vydáno v:Cell Rep
Hlavní autoři: Ikiz, Burcin, Alvarez, Mariano J., Ré, Diane B., Le Verche, Virginia, Politi, Kristin, Lotti, Francesco, Phani, Sudarshan, Pradhan, Radhika, Yu, Changhao, Croft, Gist F., Jacquier, Arnaud, Henderson, Christopher E., Califano, Andrea, Przedborski, Serge
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646662/
https://ncbi.nlm.nih.gov/pubmed/26146077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.019
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