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Mutant superoxide dismutase 1 (SOD1), a cause of amyotrophic lateral sclerosis, disrupts the recruitment of SMN, the spinal muscular atrophy protein to nuclear Cajal bodies

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are among the most common motor neuron diseases to afflict the human population. A deficiency of the survival of motor neuron (SMN) protein causes SMA and is also reported to be an exacerbating factor in the development of ALS. Ho...

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Autori principali: Kariya, Shingo, Re, Diane B., Jacquier, Arnaud, Nelson, Katelyn, Przedborski, Serge, Monani, Umrao R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392116/
https://ncbi.nlm.nih.gov/pubmed/22581780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds174
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