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Is Amyotrophic Lateral Sclerosis a Mitochondrial Channelopathy?
SOD1 is a cause of the fatal, paralytic disorder ALS. Although mechanisms underlying mutant SOD1 neurotoxicity remain uncertain, this protein associates with mitochondria. In this issue of Neuron, Israelson et al. show that mutant SOD1 binds and inhibits the mitochondrial channel VDAC1. This finding...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063527/ https://ncbi.nlm.nih.gov/pubmed/20797528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.08.010 |
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