The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression

OBJECTIVE: The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. METHODS: We studied 201 patients (80% female; median age,...

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Foilsithe in:PLoS One
Main Authors: Lamana, Amalia, López-Santalla, Mercedes, Castillo-González, Raquel, Ortiz, Ana María, Martín, Javier, García-Vicuña, Rosario, González-Álvaro, Isidoro
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2015
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646635/
https://ncbi.nlm.nih.gov/pubmed/26569609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142683
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