The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression

OBJECTIVE: The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. METHODS: We studied 201 patients (80% female; median age,...

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Vydáno v:PLoS One
Hlavní autoři: Lamana, Amalia, López-Santalla, Mercedes, Castillo-González, Raquel, Ortiz, Ana María, Martín, Javier, García-Vicuña, Rosario, González-Álvaro, Isidoro
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646635/
https://ncbi.nlm.nih.gov/pubmed/26569609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142683
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