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The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression

OBJECTIVE: The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. METHODS: We studied 201 patients (80% female; median age,...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Lamana, Amalia, López-Santalla, Mercedes, Castillo-González, Raquel, Ortiz, Ana María, Martín, Javier, García-Vicuña, Rosario, González-Álvaro, Isidoro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646635/
https://ncbi.nlm.nih.gov/pubmed/26569609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142683
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