The Minor Allele of rs7574865 in the STAT4 Gene Is Associated with Increased mRNA and Protein Expression

OBJECTIVE: The T allele of rs7574865 in STAT4 confers risk of developing autoimmune disorders. However, its functional significance remains unclear. Here we analyze how rs7574865 affects the transcription of STAT4 and its protein expression. METHODS: We studied 201 patients (80% female; median age,...

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Publicado en:PLoS One
Autores principales: Lamana, Amalia, López-Santalla, Mercedes, Castillo-González, Raquel, Ortiz, Ana María, Martín, Javier, García-Vicuña, Rosario, González-Álvaro, Isidoro
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646635/
https://ncbi.nlm.nih.gov/pubmed/26569609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142683
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