GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells

Dyskeratosis congenita is an inherited disease caused by mutations in genes coding for telomeric components. It was previously reported that expression of a dyskerin-derived peptide, GSE24.2, increases telomerase activity, regulates gene expression and decreases DNA damage and oxidative stress in dy...

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Veröffentlicht in:PLoS One
Hauptverfasser: Iarriccio, Laura, Manguán-García, Cristina, Pintado-Berninches, Laura, Mancheño, José Miguel, Molina, Antonio, Perona, Rosario, Sastre, Leandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646510/
https://ncbi.nlm.nih.gov/pubmed/26571381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142980
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