Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1

Dyskeratosis congenita (DC) is a rare telomere biology disorder, which results in different clinical manifestations, including severe bone marrow failure. To date, the only curative treatment for the bone marrow failure in DC patients is allogeneic hematopoietic stem cell transplantation. However, d...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Carrascoso-Rubio, Carlos, Zittersteijn, Hidde A., Pintado-Berninches, Laura, Fernández-Varas, Beatriz, Lozano, M. Luz, Manguan-Garcia, Cristina, Sastre, Leandro, Bueren, Juan A., Perona, Rosario, Guenechea, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844988/
https://ncbi.nlm.nih.gov/pubmed/33514435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02145-8
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