Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1

Dyskeratosis congenita (DC) is a rare telomere biology disorder, which results in different clinical manifestations, including severe bone marrow failure. To date, the only curative treatment for the bone marrow failure in DC patients is allogeneic hematopoietic stem cell transplantation. However, d...

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Detalles Bibliográficos
Publicado en:Stem Cell Res Ther
Main Authors: Carrascoso-Rubio, Carlos, Zittersteijn, Hidde A., Pintado-Berninches, Laura, Fernández-Varas, Beatriz, Lozano, M. Luz, Manguan-Garcia, Cristina, Sastre, Leandro, Bueren, Juan A., Perona, Rosario, Guenechea, Guillermo
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2021
Assuntos:
Short Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7844988/
https://ncbi.nlm.nih.gov/pubmed/33514435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02145-8
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