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Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling

Aberrant activation of sonic Hegdehog (SHH) signaling has been found to disrupt cellular differentiation in many human cancers and to increase proliferation. The SHH pathway is known to cross-talk with EGFR dependent signaling. Recent studies experimentally addressed this interplay in Daoy cells, wh...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fröhlich, Holger, Bahamondez, Gloria, Götschel, Frank, Korf, Ulrike
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4646463/
https://ncbi.nlm.nih.gov/pubmed/26571415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142646
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